Views and experiences of people with intellectual disabilities regarding intimate relationships: a qualitative metasynthesis

The aims of this review were to systematically identify, critically appraise and synthesize the results of existing qualitative literature exploring the views and experiences of intimate relationships amongst people with intellectual disabilities. Fourteen peer-reviewed articles were identified through a systematic search of eight databases, reference lists, citations, and relevant journals. The identified articles were appraised for quality, then synthesized using a metaethnography approach. No study met all quality criteria and references to ethical approval were often lacking. Interpretation of the findings suggested three key themes: the meaning of intimate relationships, external constraints and facilitators, and managing external constraints. Though many people with intellectual disabilities desire and benefit from intimate relationships, they experience restrictions that others do not, which can lead to isolation and loneliness. Intimate relationships are not always necessarily linked with sexual behavior; therefore, intimate relationships warrant their own focus in future research, as well as in education and training for people with intellectual disabilities and their caregivers. Within this, a commitment to transparency over research processes is needed, in particular with reference to how ethical approval was obtained, since this has been a shortcoming of research with this focus to date

Machina ex Deus? From Distributed to Orchestrated Agency

In this chapter, the author draws on a historical case study of the Australian wine industry to explore variations in collective agency. The inductively derived process model illustrates the emergence of a new profession of scientific win- emaking, which unfolds in three phases. Each phase is characterized by a dis- tinct form of agency: distributed agency during the earliest phase, coordinated agency during later phases, and orchestrated agency during consolidation. In addition to exploring the temporal shifts in agency, the study includes a detailed analysis of the early stages of distributed agency, examining how col- lective agency is achieved in the absence of shared intentions

Nanotools for Neuroscience and Brain Activity Mapping

Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We attribute this disparity, in part, to limitations in current methodologies. Traditional neurophysiological approaches record the activities of one neuron or a few neurons at a time. Neurochemical approaches focus on single neurotransmitters. Yet, there is an increasing realization that neural circuits operate at emergent levels, where the interactions between hundreds or thousands of neurons, utilizing multiple chemical transmitters, generate functional states. Brains function at the nanoscale, so tools to study brains must ultimately operate at this scale, as well. Nanoscience and nanotechnology are poised to provide a rich toolkit of novel methods to explore brain function by enabling simultaneous measurement and manipulation of activity of thousands or even millions of neurons. We and others refer to this goal as the Brain Activity Mapping Project. In this Nano Focus, we discuss how recent developments in nanoscale analysis tools and in the design and synthesis of nanomaterials have generated optical, electrical, and chemical methods that can readily be adapted for use in neuroscience. These approaches represent exciting areas of technical development and research. Moreover, unique opportunities exist for nanoscientists, nanotechnologists, and other physical scientists and engineers to contribute to tackling the challenging problems involved in understanding the fundamentals of brain function

Release of oxidizing fluids in subduction zones recorded by iron isotope zonation in garnet

Subduction zones are key regions of chemical and mass transfer between the Earth’s surface and mantle. During subduction, oxidized material is carried into the mantle and large amounts of water are released due to the breakdown of hydrous minerals such as lawsonite. Dehydration accompanied by the release of oxidizing species may play a key role in controlling redox changes in the subducting slab and overlying mantle wedge. Here we present measurements of oxygen fugacity, using garnet–epidote oxybarometry, together with analyses of the stable iron isotope composition of zoned garnets from Sifnos, Greece. We find that the garnet interiors grew under relatively oxidized conditions whereas garnet rims record more reduced conditions. Garnet δ56Fe increases from core to rim as the system becomes more reduced. Thermodynamic analysis shows that this change from relatively oxidized to more reduced conditions occurred during lawsonite dehydration. We conclude that the garnets maintain a record of progressive dehydration and that the residual mineral assemblages within the slab became more reduced during progressive subduction-zone dehydration. This is consistent with the hypothesis that lawsonite dehydration accompanied by the release of oxidizing species, such as sulfate, plays an important and measurable role in the global redox budget and contributes to sub-arc mantle oxidation in subduction zones

Protracted eclogite-facies metamorphism of the Dulan area, North Qaidam ultrahigh-pressure terrane: Insights on zircon growth during continental subduction and collision

Continental subduction and collision are recorded by ultrahigh-pressure (UHP) terranes; UHP terranes that form at early stages of an orogeny tend to be small and experience short residence at eclogite-facies depths, whereas terranes that form at mature stages of an orogeny tend to be larger and experience longer residence at these depths, but accurately determining eclogite-facies residence time requires a large geochronologic dataset tied to metamorphic conditions (via trace elements and/or inclusions). In the Dulan area, North Qaidam UHP terrane, China, it remains unclear whether the terrane experienced a long residence at eclogite-facies depths, marking the mature stage of an orogeny or two distinct (ultra)high pressure ([U]HP) events (with short residence times), interpreted as the transition from oceanic subduction to continental collision, where one (U)HP event is related to the former and second (U)HP event to the latter. To address this issue, we report new zircon U–Pb ages and trace-element data from eclogite and host paragneiss from the Dulan area and show that this terrane records ~42 Myr of eclogite-facies metamorphism at (U)HP conditions, similar to other large UHP terranes. Zircon from 11 eclogite and 2 gneiss samples yields weighted mean ages of 463–425 Ma, flat heavy rare earth element (HREE) patterns without negative Eu anomalies, and eclogitic mineral inclusions, indicating eclogite-facies conditions. Paragneiss metamorphic ages overlap with ages from eclogite but are generally younger, suggesting that a lack of internally generated fluids may have inhibited zircon growth and/or recrystallization until early decompression and white mica consumption in felsic gneiss generated fluids; thus, we interpret that these felsic rocks record the later stages of continental collision. Dataset patterns from all new and previously published analyses for the Dulan area (34 eclogite and 14 gneiss) suggest that metamorphic zircon in eclogite records prograde, peak and possibly early retrograde conditions, in contrast to the prediction from mass balance models that metamorphic zircon should only grow during exhumation and cooling. We reconcile our observations with these model predictions by recognizing that differential solubility can lead to grain-scale zircon growth or recrystallization over a large segment of the pressure–temperature (P–T) path even where zircon abundance decreases at the whole-rock scale

Constraints on the numerical age of the Paleocene/Eocene boundary

Here we present combined radio-isotopic dating (U-Pb zircon) and cyclostratigraphic analysis of the carbon isotope excursion at the Paleocene/Eocene (P/E) boundary in Spitsbergen, to determine the numerical age of the boundary. Incorporating the total uncertainty from both radio-isotopic and cyclostratigraphic datasets gives an age ranging from 55.728-55.964 Ma, within error of a recently proposed astronomical age of ~55.93 Ma. Combined with the assumption that the Paleocene Epoch spans twenty-five 405 kyr cycles, our new age for the boundary suggests an age of ~66 Ma for the Cretaceous/Paleogene (K/Pg) boundary. Furthermore, our P/E boundary age is consistent with the hypothesis that the onset of the Paleocene-Eocene thermal maximum (PETM) at the boundary occurred on the falling limb of a 405 kyr cycle, suggesting the event was initiated by a different mechanism to that which triggered the other early Eocene hyperthermals

10/48 Battalion, Australian Imperial Forces 1942 - 1945

"[1]0/48 Battalion A.I.F. 1942 - 1945 ________ SX23027 Pte. G. Mudge SX32781 Pte. C.E. Roesler SX23004 Sgt. N.L. Roesler SX16231 Cpl. G.R. Schlein SX23020 Cpl. P.E. Schultz SX27952 Pte. A.G. Starrick SX24790 Pte. R.L. Starkey SX27946 Pte. H.G. Sickert Maj. H.E. Moore E.D. Capt. C.V. Mattinson Capt. R.L. McDougall M.C. Cpl. Norm Datson Pte. 'Pop' Saunders"."[1]0/48 Battalion, Australian Imperial Forces, 1942 - 1945 ________ SX23027 Private G. Mudge SX32781 Private C.E. Roesler SX23004 Sergeant N.L. Roesler SX16231 Corporal G.R. Schlein SX23020 Corporal P.E. Schultz SX27952 Private A.G. Starrick SX24790 Private R.L. Starkey SX27946 Private H.G. Sickert Major H.E. Moore, Efficiency Decoration Captain C.V. Mattinson Captain R.L. McDougall, Military Cross Corporal Norm Datson Private 'Pop' SaundersThe quilt was assembled between 1992 and 1994. It was first put on display at the Northern Territory Library in 1995